Four UCSF scientists named to Institute of Medicine

For diabetics - info for diabetics - facts about diabetes Four faculty scientists in the UCSF Interpret of Medicine are among the 65 newly elected members and five foreign associates to the Institute of Medicine, part of the Civic Academy of Sciences, the Institute announced today, Oct. 13.

The new UCSF members are: • Thomas S. Bodenheimer, MD, MPH, professor, Department of Family and Community Medicine, and director, Center for Excellence in Primary Care.

• Douglas Hanahan, PhD, an American Cancer Society Research Professor in the Department of Biochemistry and Biophysics, detail, Helen Diller Family Comprehensive Cancer Center, and particle, Diabetes Center.

• Arnold Kriegstein, MD, PhD, professor of neurology, and John G. Bowes Distinguished Professor in Stem Cell and Tissue Biology and director, Institute for Regeneration Medicine.

• Michael Merzenich, PhD, professor emeritus of otolaryngology, section, Keck Center for Integrative Neuroscience.

The election brings to 79 the amount of UCSF faculty who are members of the prestigious Institute. Election to the Institute recognizes those who have mythical extensive contributions to the advancement of the medical sciences, health care and public health. It is considered one of the highest honors in these fields.

Bodenheimer has worked for the last four decades because a primary care physician in San Francisco's Mission District - - in community health centers, private practice and now at San Francisco General Hospital. His primary bag, owing to laid out in a seminal New England Logbook of Medicine Perspective in 2006, is solving the problems reverse primary care in the United States.

Trained at Harvard Medical Implant, Bodenheimer did a abode in internal medicine at UCSF. Present he was on the clinical faculty at UCSF for uncounted senescence, in 2002 he assumed a full capacity role, seeing Professor of Family and Community Medicine.

He is the co - author of the leading textbook on health policy, "Understanding Health Policy: A Clinical Reaching – 5rd edition, " McGraw - Knoll, 2008. He also co - authored "Improving Primary Care: Strategies and Tools for a Better Practice, McGraw - Knoll, " 2006.

In community health, he is not easy to revise the operations of 10 San Francisco health clinics forceful uninsured and Medi - Cal patients and teaches query stage medical students and residents in family medicine.

In the policy grounds, he's immense to stand the understanding among policy makers around the country that primary care is critical to the health care system and is in mess for few medical students are poll to practice it.

He advocates higher recompense for primary care physicians, working to make the profession more attractive to medical students, and addressing the biases censure primary care in academia.

Hanahan, a exec in the perfecting of genetically engineered mouse models of human cancers, is working to elucidate the mechanisms of cancers and to identify therapeutic strategies.

In the mid 1980s, Hanahan produced some of the first 'oncomice' – mice genetically engineered to generate organ - specific human cancers. He has used the models to request the multi - stage pathways that govern tumor formation and progression, and to look into the benefits of targeted therapies, in particular strategies aimed at blocking the sprouting of blood vessels to tumors, which rely on the blood supply for vegetation. This road is avowed considering angiogenesis inhibition.

He discovered, in collaboration with the overdue Judah Folkman at Harvard Medical Ground, the "angiogenic doorknob, " which is activated to produce new blood vessels in early stage lesions foregone indisputable tumors. A current polestar of his chore is elucidating the "organ of genesis" of tumors, in which manifold cell types assemble with overtly transformed cells to construction aberrant, expansive microenvironments of cancer.

He has also used genetically engineered mouse models to roast mechanisms of self tolerance to the pancreatic beta cells, which are destroyed by the unsusceptible system in type I diabetes; he fix, for quotation exceptional tolerance - scrutiny cells in the thymus that willing the beta - cell specific insulin gene.

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Owing to a graduate student, Hanahan developed uplifted efficiency plasmid transformation methods and E. coli strains that posses facilitated DNA cloning procedures; his rat race on E. coli transformation ( the production of "competent cells" ) has facilitated molecular genetics research in the verve sciences.

Through the founding director of the UCSF Institute for Regeneration Medicine, Kriegstein has led the advancing of one of the leading institutes of its kind in the United States. He previously was the founding director of the Neural Stem Cell Center at Columbia University.

The Institute encompasses some 60 labs investigating fundamental questions about human maturation, with the ambition of illuminating and treating a broad area of diseases and disorders, from love disease and diabetes to birth defects, osteoporosis and cancer. Over a neurologist, Kriegstein is absorbed in meaningful if stem cells could basically be used to treat diseases in which the neurons of the brain retain died or been pained, because in Parkinson's disease, stroke, spinal leash injury, Huntington's disease and amyotrophic sidelong sclerosis ( ALS ).

Last Walk, Kriegstein was awarded the second largest comprehensive grant from the California Institute for Regeneration Medicine, for a collaborative study involving four labs at UCSF tough to prompt human embryonic stem cells to specialize now a particular type of nerve cell, published over an inhibitory neuron, that could be used to water the electrical hustle in the brain circuits of patients with Parkinson's disease and epilepsy.

Merzenich's pioneering research during the last three decades has free the brain ' s capacity to rewire itself. He has used this erudition to evolve romance interventions aimed at treating a wide gamut of neurological diseases and disabilities.

In the 1980s, he developed the rudimentary neural prosthesis - - the cochlear implant - - which worked being it engaged the brain in learning to hear in a new way. In the mid 1990s, he developed software programs for talking and learning disabilities that commission by accelerating the speed at which issue red tape sound. His patented findings led to his co - founding in 1996 of Specialized Learning, a therapeutic software company in Oakland, California.

Today, he is exploring tale strategies for treating schizophrenia, bipolar disorder, functional losses in usual aging, mild logical impairment, Alzheimer's disease, acquired movement disorders, autism, and learning, words and declaiming impairments in spawn.

In 2003, he co - founded Trust Science, in San Francisco, which is carrying out software - based onset trouble on a numeral of neurological conditions and disorders.

The Institute of Medicine's total active membership is now 1, 576 and the character of foreign associates is 89. With heavier 71 members holding emeritus status, IOM ' s total membership is now 1, 736.

Established in 1970 by the National Academy of Sciences, the Institute of Medicine is a national resource for independent, scientifically informed analysis and recommendations on issues related to human health. With their election, members make a commitment to devote a significant amount of volunteer time as members of IOM study committees.

Current active members elect new members from among candidates nominated for their professional achievement and commitment to service. The Institute ' s charter stipulates that at least one - quarter of the membership be selected from outside the health professions, from such fields as the natural, social, and behavioral sciences, as well as law, administration, engineering, and the humanities.

UCSF is a leading university that advances health worldwide by conducting advanced biomedical research, educating graduate students in the life sciences and health professions, and providing complex patient care.

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